P2X4 Receptor-Dependent Ca2+ Influx in Model Human Monocytes and Macrophages
نویسندگان
چکیده
منابع مشابه
P2X4 Receptor-Dependent Ca2+ Influx in Model Human Monocytes and Macrophages
Monocytes and macrophages express a repertoire of cell surface P2 receptors for adenosine 5'-triphosphate (ATP) a damage-associated molecular pattern molecule (DAMP), which are capable of raising cytoplasmic calcium when activated. This is achieved either through direct permeation (ionotropic P2X receptors) or by mobilizing intracellular calcium stores (metabotropic P2Y receptors). Here, a side...
متن کاملChloride influx aggravates Ca2+-dependent AMPA receptor-mediated motoneuron death.
AMPA receptor-mediated excitotoxicity has been implicated in the pathogenesis of stroke, neurotrauma, epilepsy, and many neurodegenerative diseases such as motoneuron disease. We studied the role of Cl- in AMPA receptor-mediated Ca2+-dependent excitotoxicity in cultured rat spinal motoneurons. Using the gramicidin perforated patch-clamp technique, the intracellular Cl- concentration could be ca...
متن کاملHuman Monocytes and Macrophages
PPD-sensitized monocytes and macrophages from tuberculin-positive subjects are both capable of inducing blastogenic transformation of autologous lymphocytes. Incorporation of thymidine-(3)H and morphological transformation were always greater in lymphocyte cultures containing macrophages than in those containing monocytes. More lymphocytes entered the first detectable S phase in cultures contai...
متن کاملstore-regulated Ca2+ influx in human neutrophils
1. It is not known to what extent the emptying of intracellular Ca2+ stores participates in the mediation of chemoattractantinduced Ca2+ influx in humawneutrophils. To study this question, we compared the properties of bivalent-cation influx in response to the chemoattractant N-formyl-L-methionyl-L-leucyl-L-phenylalanine (f-MLP) and to the microsomal Ca2+-ATPase inhibitor thapsigargin. 2. The i...
متن کاملresistance training, interleukin-10, lymphocytes, monocytes, macrophages.
مقدمه: پرفشارخونی یکی از بیماریهای همراه با بیماری دیابت نوع 2 است که در بیشتر بیماران دیابتی نوع 2 دیده می‌شود. هدف از انجام این تحقیق بررسی اثر ورزش ایروبیک بر روی فشارخون زنان دیابتی نوع 2 است. روش پژوهش: تعداد 32 بیمار دیابتی نوع 2 که دارای فشارخون بالا بودند به صورت تصادفی به دو گروه تقسیم شدند: گروه ورزش ایروبیک (16 نفر) و گروه کنترل (بدون ورزش) (16 نفر)...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2017
ISSN: 1422-0067
DOI: 10.3390/ijms18112261